Meftal Drug Security Alert: The Indian Pharmacopoeia Fee underneath the Union Ministry of Well being & Household Welfare has issued a drug security alert on mefenamic acid, a drugs offered underneath the model title Meftal. The drug security alert was issued on November 30, 2023, as a result of a preliminary evaluation carried out by the Pharmacovigilance Programme of India (PvPI), an Indian authorities organisation which identifies and responds to drug security issues, revealed some antagonistic drug reactions brought on by mefenamic acid.
It was discovered to trigger drug rash with eosinophilia and systemic signs (DRESS) syndrome.
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What’s DRESS syndrome?
The DRESS syndrome is a extreme, distinct, and idiosyncratic drug response, which is an unpredictable response that happens in solely a small proportion of sufferers receiving the drug, and which doesn’t contain identified pharmacological properties of the drug. The DRESS syndrome has a chronic latency interval, which signifies that the time interval between publicity to the drug and the looks of signs is lengthy.
The signs of the DRESS syndrome can begin showing about two to eight weeks after consuming the drug. The signs embrace fever, a variety of mild-to-severe systemic occurrences, rash, lymphadenopathy, or swelling of the lymph nodes, and eosinophilia, or the presence of too many eosinophils within the physique, in response to the US Nationwide Institutes of Well being (NIH).
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The Indian Pharmacopoeia Fee has suggested healthcare professionals, sufferers and shoppers to carefully monitor the potential of prevalence of the DRESS syndrome with using mefenamic acid.
Individuals who observe such reactions have been requested to report back to the Nationwide Coordination Middle underneath the PvPI by filling the Suspected Hostile Drug Reactions Reporting Type, or the Medicines Facet Impact Reporting Type for Shoppers.
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The shape could be crammed by means of an Android cell utility referred to as ADR PvPI.
Mefenamic acid is used to deal with rheumatoid arthritis, dysmenorrhoea, irritation, dental ache, osteoarthritis, delicate to average ache, and fever.
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